Back-to-back posting – I wanted to talk about the growing volume of TCR structures in the PDB. A couple of weeks ago, I presented my database to the group (STCRDab), which is now available at http://opig.stats.ox.ac.uk/webapps/stcrdab.
Unlike other databases, STCRDab is fully automated and updates on Fridays at 9AM (GMT), downloading new TCR structures and annotating them with the IMGT numbering (also applies for MHCs!). Although the size of the data is significantly smaller than, say, the number of antibody structures (currently at 3000+ structures and growing), the recent approval of CAR therapies (Kymriah, Yescarta), and the rise of interest in TCR engineering (e.g. Glanville et al., Nature, 2017; Dash et al., Nature, 2017) point toward the value of structures.
Feel free to read more in the paper, and here are some screenshots. 🙂
Look! 5men, literally.