{"id":1173,"date":"2013-10-01T19:19:38","date_gmt":"2013-10-01T18:19:38","guid":{"rendered":"http:\/\/www.blopig.com\/blog\/?p=1173"},"modified":"2013-10-01T19:23:18","modified_gmt":"2013-10-01T18:23:18","slug":"publication-arginine-methylation-dependent-reader-writer-interplay-governs-growth-control-by-e2f-1","status":"publish","type":"post","link":"https:\/\/www.blopig.com\/blog\/2013\/10\/publication-arginine-methylation-dependent-reader-writer-interplay-governs-growth-control-by-e2f-1\/","title":{"rendered":"[Publication] Arginine Methylation-Dependent Reader-Writer Interplay Governs Growth Control by E2F-1"},"content":{"rendered":"<p>If you are familiar with the <a href=\"http:\/\/www.resverlogix.com\/blog\/2013\/03\/12\/readers-writers-erasers-what-exactly-does-this-mean-in-epigenetics-2\/\">reader, writer &amp; eraser<\/a> concepts or you are passionate about <em>epigenetics<\/em> and <em>arginines<\/em>, this <a href=\"http:\/\/www.cell.com\/molecular-cell\/abstract\/S1097-2765%2813%2900639-4\">recent publication<\/a> might be of interest to you. The study addresses the transcription factor E2F-1, which plays a crucial role in the control of cell cycle and is linked with cancer. Like <a href=\"http:\/\/en.wikipedia.org\/wiki\/Yin_and_yang\">Yin-yang<\/a>, it has opposing functional roles: to promote cell-cycle progression and to induce apoptosis. The results demonstrate that the biological outcome of E2F-1 activity is affected by arginine methylation marks. While asymmetric arginine methylation causes apoptosis, the symmetrical methylation results in proliferation. This reader-writer interplay determined by the two types of marks governs the function of E2F-1 and potentially the fate of the cell.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>If you are familiar with the reader, writer &amp; eraser concepts or you are passionate about epigenetics and arginines, this recent publication might be of interest to you. The study addresses the transcription factor E2F-1, which plays a crucial role in the control of cell cycle and is linked with cancer. Like Yin-yang, it has [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","wikipediapreview_detectlinks":true,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"ngg_post_thumbnail":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[48],"tags":[],"ppma_author":[502],"class_list":["post-1173","post","type-post","status-publish","format-standard","hentry","category-publication"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"authors":[{"term_id":502,"user_id":5,"is_guest":0,"slug":"leila","display_name":"Leila Alexander","avatar_url":"https:\/\/secure.gravatar.com\/avatar\/cd34bb0d309852587d0d0ef3cd44db9533e3fd4fe42c20dd9282128a05a88af5?s=96&d=mm&r=g","0":null,"1":"","2":"","3":"","4":"","5":"","6":"","7":"","8":""}],"_links":{"self":[{"href":"https:\/\/www.blopig.com\/blog\/wp-json\/wp\/v2\/posts\/1173","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.blopig.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.blopig.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.blopig.com\/blog\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/www.blopig.com\/blog\/wp-json\/wp\/v2\/comments?post=1173"}],"version-history":[{"count":13,"href":"https:\/\/www.blopig.com\/blog\/wp-json\/wp\/v2\/posts\/1173\/revisions"}],"predecessor-version":[{"id":1186,"href":"https:\/\/www.blopig.com\/blog\/wp-json\/wp\/v2\/posts\/1173\/revisions\/1186"}],"wp:attachment":[{"href":"https:\/\/www.blopig.com\/blog\/wp-json\/wp\/v2\/media?parent=1173"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.blopig.com\/blog\/wp-json\/wp\/v2\/categories?post=1173"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.blopig.com\/blog\/wp-json\/wp\/v2\/tags?post=1173"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/www.blopig.com\/blog\/wp-json\/wp\/v2\/ppma_author?post=1173"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}